If you get tilt & turn double glazing your in-frame honeycomb blinds no longer work because the head of the blinds get in the way of the tilt. So instead you have blinds which open top down, and close bottom up. It works by simply having teeth at the siderails so that when you tilt the handle it clips it out of the side rails and you move it up or down and then it clips back in when you put it back to flat.
I know there are topdown/bottomup honeycomb blinds but they use a string and I imagine that would get in the way of it opening and closing.